作为《Mrs.Cop》的延续，故事也会按照上一部继续发展。《Mrs.Cop2》讲述了崔英真因个人原因进行短暂休息，而重案组则迎来了一名新组长，焕然一新的重案小组进入了对全新案件地调查。
뉴욕에서 온 슈퍼 미세스캅 고윤정이, ‘007 시리즈의 M’을 연상시키는 박종호, 절대 악역 이로준과 함께 만드는 대중적 수사활극.
Six years ago, detective Go Yoon Jung (Kim Sung Ryung) arrested a taxi driver for murdering a passenger. She later realized that the taxi driver was innocent after receiving crucial evidence from the real murderer. Her prosecutor husband helped cover up the truth and sent her to the U.S. In order to trace the murderer,Yoon Jung returns to Korea and forms a detective squad to solve cold cases similar to the past murder case.However, all the clues point to the same person – young entrepreneur Lee Ro Joon (Kim Bum).
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